![]() Zhang J-M et al (2016) Simplified models of non-invasive fractional flow reserve based on CT images. Int J Numer Methods Biomed Eng 31(4): e02708. Zhang J-M et al (2015) Hemodynamic analysis of patient-specific coronary artery tree. Int J Numer Methods Biomed Eng 30(6):659–680. Zhang J-M et al (2014) Perspective on CFD studies of coronary artery disease lesions and hemodynamics: a review. Zhong L et al (2018) Application of patient-specific computational fluid dynamics in coronary and intra-cardiac flow simulations: challenges and opportunities. Lee J, Smith NP (2012) The multi-scale modelling of coronary blood flow. Ĭhaichana T, Sun Z, Jewkes J (2012), Computational fluid dynamics analysis of the effect of plaques in the left coronary artery. Atherosclerosis 211(2):445–450Ĭhaichana T, Sun Z, Jewkes J (2011) Computation of hemodynamics in the left coronary artery with variable angulations. Knight J, Olgac U, Saur SC, Poulikakos D, Marshall W, Kurtcuoglu V (2010) Choosing the optimal wall shear parameter for the prediction of plaque location-a patient-specific computational study in human right coronary arteries. Hilgenstock A, Ernst R (1996) Analysis of installation effects by means of computational fluid dynamics-CFD vs experiments? Flow Meas Instrum 7(3–4): 161–171 Interact Cardiovasc Thorac Surg 17(6): 950–955. įragomeni G et al (2013) Apicoaortic conduit and cerebral perfusion in mixed aortic valve disease: a computational analysis. Acta Bioeng Biomech 18(3):3–9Ĭaruso MV et al (2017) Influence of IABP-Induced abdominal occlusions on aortic hemodynamics: a patient-specific computational evaluation. Ĭaruso MV et al (2016) Computational analysis of aortic hemodynamics during total and partial extracorporeal membrane oxygenation and intra-aortic balloon pump support. Samady H et al (2011) Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease. Gibson CM et al (1993) Relation of vessel wall shear stress to atherosclerosis progression in human coronary arteries. Parisi AF, Edward DF, Hartigan OP (1992) A comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease. Circulation 62(2):240–248Ĭhang K, Prasad E, Olsen R (2000) Textbook of angiology. Harris PJ et al (1980) The prognostic significance of 50% coronary stenosis in medically treated patients with coronary artery disease. Heitzer T et al (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. Sans S, Kesteloot H, Kromhout D (1997) The burden of cardiovascular diseases mortality in Europe: task force of the European Society of cardiology on cardiovascular mortality and morbidity statistics in Europe. Wilkins E et al (2017) European cardiovascular disease statistics 2017. Moreover, the application can be a valid tool to help in the evaluation of the condition and in the follow-up of the coronary affected by pathology. Being in possession of a predictive tool for disturbed flow factors may be important for the location and development of atherosclerotic plaque. The application, based on Java, allows users to view the results of simulations performed on a coronary anatomy that can be customized with a stenosis of different degrees and positions. The aim of the following study was to develop and test an application that is able to evaluate specific hemodynamic shear stress indicators in coronary arteries at different percentages of stenosis and in different patients’ specific conditions. It is, therefore, useful to evaluate the role of the stress state of the endothelial layer of the arterial tissue, both for the maintenance of the blood circulation and for the implications in presence of a pathology that can lead to thromboembolic complications. Most of them occur because of an atherosclerotic plaque developing within a coronary artery, which can cause a narrowing of the vessel lumen (coronary stenosis) or even break it. Cardiovascular diseases are among the main causes of morbidity, disability, and mortality. ![]()
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